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When central sensitization occurs, these fibers begin triggering pain circuits they were never designed to activate

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[6] When bound on the endothelial cells of the liver, it is often found bound to heparan sulfate proteoglycans (HSPG), keeping HL inactive and unable to bind to HDL (high-density lipoprotein) or IDL (intermediate-density lipoprotein)

Appendicitis as an early manifestation of subsequent Malignancy: an asian population study